Agricola, governor of Cappadocia, came to Sebaste to persecute Christians. His huntsmen went into the forests of Argeus to find wild animals for the arena games, and found many waiting outside Blaise's cave. Discovered in prayer, Blaise was arrested, and Agricola tried to get him to recant his faith. While in prison, Blaise ministered to and healed fellow prisoners, including saving a child who was choking on a fish bone; this led to the blessing of throats on Blaise's feast day.
Thrown into a lake to drown, Blaise stood on the surface and invited his persecutors to walk out and prove the power of their gods; they drowned. When he returned to land, he was martyred by being beaten, his flesh torn with wool combs (which led to his association with and patronage of those involved in the wool trade), and then beheading.
St. Blaise has been extremely popular for centuries in both the Eastern and Western Churches and many cures were attributed to him. In 1222 the Council of Oxford prohibited servile labour in England on his feast. He is one of the Fourteen Holy Helpers, and he is invoked especially for afflictions of the throat.
— Excerpted from The Church's Year of Grace, Pius Parsch
O God, who makest us glad with the yearly festival of blessed Blaise, thy Martyr and Bishop: mercifully grant that, as we now observe his heavenly birthday; so we may likewise rejoice in his protection; through Jesus Christ thy Son our Lord, who liveth and reigneth with thee, in the unity of the Holy Spirit, ever one God, world without end. Amen.