St. Jerome was eventually ordained, and settled into the life of a parish priest. But soon after his ordination, God began to call St. Jerome into a new ministry – not in a parish, but a ministry which would reach far beyond a single parish. A terrible plague was sweeping across Europe, and there was widespread famine throughout northern Italy where St. Jerome was. He began caring for the sick and feeding the hungry at his own expense. While serving the sick and the poor, he made the decision to devote himself and all his resources to assist others, particularly for the care of abandoned children. He founded three orphanages and a hospital.
In about the year 1532, Jerome and two other priests established a religious congregation dedicated to the care of orphans and the education of youth. Jerome died in 1537 from a disease he caught while tending the sick. He was eventually canonized, and was named the universal patron of orphans and abandoned children.
O God, the Father of mercies, who didst raise up Saint Jerome Emiliani to be a defender and father of the fatherless: vouchsafe, through his merits and intercession; that we may faithfully guard thy spirit of adoption, whereby we are called and are indeed thy children; through Jesus Christ thy Son our Lord, who liveth and reigneth with thee, in the unity of the Holy Spirit, ever one God, world without end. Amen.